By Chuang Lu, Albert P. Li
The technological know-how and utilized techniques of enzyme inhibition in drug discovery and improvement
Offering a special method that comes with either the pharmacologic and pharmaco-kinetic points of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the clinical recommendations and experimental techniques on the topic of enzyme inhibition as utilized in drug discovery and drug development.
With chapters written through over fifty top specialists of their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by way of realizing the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The publication discusses:
The drug discovery technique, together with drug discovery approach, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and defense biomarker assessment
The manipulations of drug metabolizing enzymes and transporters in addition to the unfavourable effects, equivalent to drug–drug interactions
The inhibition of a number of significant drug goal pathways, similar to the GPCR pathway, the NFkB pathway, and the ion channel pathway
Through this targeted, single-source reference at the basics of drug discovery and improvement, researchers in drug metabolism and pharmacokinetics (DMPK) will examine and enjoy goal biology in drug discovery; discovery biologists and medicinal chemists also will expand their knowing of DMPK.